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Because tesofensine has a half-life of about 9 days, the drug builds up over the first 4-6 weeks before reaching steady state

For some individuals, this means experiencing softer stools or mild diarrhoea during early treatment

Another reason could be that, as semaglutide suppresses appetite, reduces your hunger and makes you feel fuller, eating larger portions of food might cause nausea, bloating, or discomfort